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Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated with animal weight while extrapolating the doses of therapeutic agents among the species.
In addition, all urine was collected for h and analyzed for conjugated metabolites of the above steroids. There was a rapid disappearance of 2-OHE 1 from the blood, such that by — min, none was measurable. The CRs for these compounds were 0.
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