Key 67 breast

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Context: Breast cancer is the most common malignancy in females. It is routinely classified according to the WHO histological typing. However, there is also a molecular classification of breast cancer which is routinely substituted with surrogate subtypes based on expression of estrogen, progesterone, and human epidermal growth factor receptor 2 receptors and proliferation index PI.

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Triple negative breast cancer TNBC is a subgroup of breast cancer lacking estrogen receptor ER and progesterone receptor PR expression as well as human epithelial growth factor receptor 2 HER2 amplification. From the histological perspective, TNBC is a common immunohistochemical IHC status for a number of tumors with heterogeneous clinical presentations [ 1 ]. Recent study identified six TNBC subtypes that display unique profiles [ 2 ].

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Context: Despite the fact that breast cancer BC is a major health issue, very few studies describe its characteristics in the Middle East. Aim: The aim of this study was to evaluate the use and value of Ki as a prognostic marker in BC and associations between Ki, clinical, and histopathological parameters were evaluated. Subjects and Methods: In a retrospective study, BC women and invasive ductal carcinoma were included to our study in Kermanshah city, Iran.

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The proliferation marker Ki is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. The purpose of this study was to evaluate the routine use and value of Ki as a prognostic marker, and to analyze the associations between Ki and common histopathological parameters in the routine clinical setting. Data from the clinical cancer registry Regensburg Bavaria, Germany were analyzed.

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Background: Tumor markers have a key role in guiding breast cancer management protocols and predicting prognosis. Objective: The aim of the study is to explore the role of Ki expression in breast cancer and correlate it to well-known indicators of invasiveness such as age, tumor size, grade, hormonal receptors, and lymph nodes involvement. Data regarding patient's demographics, tumor size, histological type and grade, nuclear grade, and lymph node involvement were obtained from medical records.

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Search for the other articles from the author in: Google Scholar PubMed. Total Citations. Submitted: Feb 17, Published: Feb 17,

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Ki plays an important function in cell division, but its exact role is still unknown. Moreover, few works regarding its overall function were published. The present study evaluated the clinical significance of Ki index as a prognostic marker and predictor of recurrence in different molecular subtypes of breast cancer.

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The Ki67 antigen, which encodes two protein isoforms with molecular weights of and kDa, was originally identified by Scholzer and Gerdes in the early s 1. It is present during all active phases of the cell cycle G1, S, G2 and Mbut is absent in resting cells G0 23. In later phases of mitosis during anaphase and telophasea sharp decrease in Ki67 levels occurs 4.

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Patients and Methods: We recruited breast cancer patients who undertook operation with no prior chemotherapy. Ten-year survival outcomes were evaluated by clinicopathological factors. Results: Significant univariate prognostic factors were: T factor, N factor, preoperative values of tumor markers, and biological factors.

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